PENDISTRIN-SH® Tube 6 ML

Manufacturer/Marketer: Zenex Animal Health India Pvt. Ltd.
Product Type: Veterinary Intramammary Antibiotic & Anti-inflammatory Infusion
Therapeutic Category: Intramammary Antibiotic / Mastitis Therapy
Target Species: Cattle, Buffaloes, Sheep & Goats
Presentation: 6 mL intramammary tube
Route: Intramammary
Prescription Status: Veterinary prescription medicine

Zenex currently lists PENDISTRIN-SH as a 6 mL intramammary product for cattle, buffaloes, sheep and goats. 

Composition

Each 6 mL tube contains:

• Procaine Penicillin G IP – 1,00,000 units
• Streptomycin Sulphate IP – 100 mg
• Sulfamerazine BP (Vet) – 500 mg
• Hydrocortisone Acetate IP – 20 mg
• Plastobase q.s. to make – 6 mL 

The formulation combines antibacterial agents with hydrocortisone, a corticosteroid that provides local anti-inflammatory activity.

Clinical Description

PENDISTRIN-SH is a combination intramammary preparation designed for the treatment of acute and chronic mastitis in susceptible livestock.

The antibacterial combination of Procaine Penicillin G, Streptomycin and Sulfamerazine provides activity against susceptible mastitis-associated bacteria, while Hydrocortisone Acetate helps control local inflammatory responses in the affected udder quarter.

Historical manufacturer literature specifically identifies PENDISTRIN-SH for acute and chronic mastitis, while Zenex's current information continues to classify it as an intramammary infusion. 

Indications / Recommended Uses

PENDISTRIN-SH is used for:

• Acute mastitis
• Chronic mastitis
• Bacterial intramammary infections
• Mastitis associated with susceptible Gram-positive and Gram-negative organisms
• Control of associated udder inflammation
• Treatment of affected udder quarters in appropriate lactating animals under veterinary supervision. 

Older veterinary references specifically mention susceptible organisms such as Streptococcus* spp., Staphylococcus spp. and *Escherichia coli. 

Dosage & Administration

Route: Intramammary infusion.

A historical Zydus Animal Health therapeutic catalogue gives the following regimen:

One complete tube into the affected udder quarter after each milking for 2–3 days. 

Zenex's current product page confirms the intramammary route, but does not publish a detailed dosing schedule. Therefore, for Rayavets the preferred instruction is:

Dosage & duration: One tube intramammarily into the affected quarter, or as directed by the Registered Veterinary Practitioner. 

Before administration, the affected quarter should be completely milked out and the teat end thoroughly cleaned and disinfected. Avoid contaminating the applicator tip during administration.

Key Benefits

PENDISTRIN-SH provides:

• Combination antibacterial therapy
• Treatment support for acute and chronic mastitis
• Broad antibacterial coverage from its multi-drug formulation
• Local anti-inflammatory support from Hydrocortisone Acetate
• Direct delivery of medication into the affected udder quarter
• Convenient single-dose 6 mL intramammary tube
• Established use in veterinary mastitis management. 

Contraindications & Precautions

Do not use in animals known to be hypersensitive to penicillins, aminoglycosides, sulfonamides, corticosteroids or any component of the formulation.

Strict hygiene should be maintained during intramammary administration to prevent introducing additional microorganisms into the teat canal.

Treatment should preferably follow appropriate veterinary examination, particularly in severe, recurrent or non-responsive mastitis.

Use only under the direction of a Registered Veterinary Practitioner.

Withdrawal Period

Because PENDISTRIN-SH is used in food-producing animals, appropriate milk and meat withdrawal periods must be observed.

Zenex's current public product page does not state specific withdrawal periods. Therefore, Rayavets should not publish an assumed milk or meat withdrawal time. Follow the current product label/pack insert and prescribing veterinarian's instructions. 

Possible Adverse Effects

Potential adverse reactions may include:

• Local irritation or discomfort
• Hypersensitivity reactions to penicillin or other ingredients
• Rare allergic reactions
• Alteration of local udder flora with inappropriate or prolonged antimicrobial use

Any severe or unexpected reaction should be evaluated promptly by a veterinarian.

Storage

Store according to the instructions provided on the current manufacturer-approved label.

Keep the tubes in their original packaging in a cool, dry place, protected from direct sunlight, excessive heat and contamination.

Keep out of reach of children.

Important Warning

FOR ANIMAL TREATMENT ONLY. NOT FOR HUMAN USE.

FOR INTRAMAMMARY USE ONLY.

Use only under the prescription/direction of a Registered Veterinary Practitioner.

Antibiotics should be used responsibly and only for appropriately diagnosed bacterial infections. Observe the current manufacturer's milk and meat withdrawal instructions before products from treated animals enter the human food chain.

Rayavets Short Description

PENDISTRIN-SH Tube 6 ML by Zenex Animal Health India Pvt. Ltd. is a veterinary intramammary antibiotic and anti-inflammatory preparation used for the treatment of acute and chronic mastitis. Each 6 mL tube contains Procaine Penicillin G 1,00,000 units + Streptomycin Sulphate 100 mg + Sulfamerazine 500 mg + Hydrocortisone Acetate 20 mg in Plastobase. It provides combined antibacterial activity and local anti-inflammatory support directly in the affected udder quarter. Administer intramammarily as directed by a Registered Veterinary Practitioner and strictly observe applicable milk and meat withdrawal instructions. For animal treatment only.