SULPHADIMIDINE SODIUM (VET) Injection 100 ML – ELANCO

Manufacturer/Marketer: Elanco Animal Health
Product Type: Veterinary Injectable Antibacterial / Antiprotozoal
Therapeutic Category: Sulfonamide Antibacterial & Anticoccidial
Target Species: Livestock, as directed by a veterinarian
Pack Size: 100 ML Vial
Prescription Status: Veterinary prescription medicine

Elanco India is specifically listed as the manufacturer/marketer of the Sulphadimidine Sodium (Vet) Injection 100 ML product. Independent Indian veterinary product lists also identify Sulphadimidine 100 ML under Elanco India. 

Composition

The veterinary injectable formulation is:

• Sulphadimidine Sodium — 33.33% w/v
• Equivalent to approximately 333 mg Sulphadimidine Sodium per ML
• Sterile injectable vehicle — q.s.

Indian veterinary procurement specifications likewise identify Sulphadimidine injection as Sulphadimidine Sodium 33⅓% solution in a 100 ML bottle. 

Important correction: although this product is sometimes informally entered as “Sulphadimidine Hydrochloride,” the injectable veterinary formulation I can verify is Sulphadimidine Sodium, not Sulphadimidine Hydrochloride. 

Clinical Description

Sulphadimidine is a systemic sulfonamide antimicrobial and anticoccidial agent used in veterinary medicine.

It acts as a competitive inhibitor of bacterial folate synthesis, interfering with the production of folic acid required for growth and multiplication of susceptible microorganisms. Its action is primarily bacteriostatic.

The injectable formulation provides systemic exposure and is used when rapid or reliable parenteral therapy is considered appropriate by the veterinarian.

Indications / Recommended Uses

Sulphadimidine Injection may be prescribed for susceptible bacterial or protozoal conditions such as:

• Haemorrhagic septicaemia
• Pasteurellosis
• Bacterial respiratory infections / pneumonia
• Bacterial enteritis
• Calf scour associated with susceptible organisms
• Colibacillosis
• Salmonellosis
• Foot rot
• Septicaemic bacterial infections
• Certain susceptible mastitis-associated infections
• Coccidiosis

Use should be based on veterinary diagnosis and, where appropriate, antimicrobial susceptibility testing.

Usage Instructions

For veterinary administration only.

For 33.3% Sulphadimidine formulations, veterinary references commonly use a higher initial dose followed by approximately half of the initial dose on subsequent treatment days. Published veterinary drug references also describe IV administration for 333 mg/mL Sulphadimidine formulations. 

However, the exact dose, route, frequency and treatment duration for the Elanco product should follow its current pack insert or a veterinarian's prescription rather than being extrapolated from another manufacturer's formulation.

Key Benefits

Sulphadimidine Sodium Injection provides systemic sulfonamide antimicrobial activity and also has useful anticoccidial activity.

It may help control susceptible respiratory, gastrointestinal and systemic bacterial infections while also providing therapeutic activity against susceptible coccidia.

The injectable formulation can be useful when oral administration is inappropriate or reliable systemic therapy is required.

Precautions

Use only under veterinary supervision.

Ensure adequate hydration during sulfonamide therapy. Use cautiously in animals with:

• Renal impairment
• Liver dysfunction
• Severe dehydration
• Blood disorders
• Known sulfonamide hypersensitivity

Unnecessary or inappropriate antimicrobial use should be avoided because it contributes to antimicrobial resistance.

Possible Adverse Effects

Possible adverse reactions associated with systemic sulfonamide therapy include:

• Injection-site irritation
• Gastrointestinal disturbances
• Reduced appetite
• Crystalluria
• Renal complications, particularly in dehydrated animals
• Hypersensitivity reactions
• Hematological abnormalities during prolonged or inappropriate treatment

If a significant adverse reaction develops, discontinue treatment and seek veterinary advice.

Storage

Store according to the instructions printed on the current Elanco product label, protected from excessive heat and direct sunlight.

Keep the vial securely stored and out of reach of children and unauthorized persons. Do not use a vial showing contamination, leakage or abnormal changes in the solution.

Important Warning

FOR VETERINARY USE ONLY.

Sulphadimidine Sodium Injection is a prescription veterinary antimicrobial. Correct diagnosis, dosage and treatment duration are important to reduce treatment failure and antimicrobial resistance.

For food-producing animals, follow the milk and meat withdrawal periods stated on the current Elanco label. Withdrawal periods should not be copied from another Sulphadimidine product because approved conditions can differ.

Rayavets Short Description

Sulphadimidine Sodium (Vet) Injection 100 ML by Elanco India is a veterinary sulfonamide antimicrobial and anticoccidial injection containing Sulphadimidine Sodium 33.33% w/v (approximately 333 mg/mL). It is used under veterinary supervision for susceptible bacterial respiratory, gastrointestinal and systemic infections and coccidiosis in livestock. Sulphadimidine works by interfering with microbial folic-acid synthesis, thereby inhibiting the growth of susceptible organisms. Administer only according to the veterinarian-prescribed dose, route and duration, and observe the applicable milk and meat withdrawal periods.