SULPHA® Bolus

Manufacturer/Marketer: Zenex Animal Health India Pvt. Ltd.
Product Type: Veterinary Oral Antibacterial Bolus
Therapeutic Category: Sulfonamide Antibacterial / Anti-Microbial
Target Species: Cattle, Buffaloes, Sheep & Goats
Presentation: Blister of 4 boli
Route: Oral
Prescription Status: Veterinary Prescription Antibacterial Medicine

Composition

Each uncoated bolus contains:

• Sulphadimidine IP – 5 g
• Excipients – q.s. 

Sulphadimidine (Sulfadimidine/Sulfamethazine) is a systemic sulfonamide antibacterial that inhibits bacterial folate synthesis and thereby suppresses multiplication of susceptible bacteria.

Clinical Description

SULPHA Bolus is an oral veterinary sulfonamide antibacterial medicine containing Sulphadimidine 5 g per bolus.

It is intended for treatment of susceptible bacterial infections in livestock. Manufacturer product literature specifically lists calf scours, bacterial enteritis and acute bacterial infections among its major indications. 

Sulphadimidine is primarily bacteriostatic, interfering with folic-acid synthesis required for bacterial growth and multiplication.

Indications / Recommended Uses

SULPHA Bolus is used under veterinary supervision for:

• Calf scours of susceptible bacterial origin
• Bacterial enteritis
• Acute susceptible bacterial infections
• Gastrointestinal bacterial infections
• Other sulphadimidine-sensitive infections where sulfonamide therapy is considered appropriate

The product should be used for susceptible bacterial disease, rather than indiscriminately for diarrhoea from parasitic, viral, dietary or other non-bacterial causes. 

Dosage & Administration

Route: Oral

Historical manufacturer product literature specifies:

Initial dose: 1–2 boli per 50 kg body weight

Subsequent dose: Half of the initial dose daily for 3–5 days. 

Adequate access to drinking water is particularly important during sulfonamide treatment.

The actual dose and duration should be determined according to the animal's body weight, clinical condition and veterinary diagnosis.

Key Benefits

SULPHA Bolus provides:

• Sulphadimidine 5 g per bolus
• Systemic sulfonamide antibacterial activity
• Treatment support for bacterial enteritis
• Management of susceptible bacterial calf scours
• Use in susceptible acute bacterial infections
• Convenient oral bolus administration
• Established use in livestock antimicrobial therapy
• Suitable for cattle, buffaloes, sheep and goats under veterinary supervision. 

Contraindications & Precautions

Do not administer to animals with known hypersensitivity to sulfonamides.

Use cautiously in animals with:

• Kidney impairment
• Liver dysfunction
• Severe dehydration
• Urinary tract obstruction or impaired urine production
• Blood disorders associated with sulfonamide therapy

Ensure animals have adequate access to clean drinking water, unless otherwise directed by the veterinarian.

Treatment should be completed for the prescribed duration. Inappropriate dosing or unnecessary antimicrobial use may contribute to antimicrobial resistance.

Withdrawal Period

SULPHA Bolus is intended for food-producing animals, so applicable milk and meat withdrawal periods must be strictly observed.

The current Zenex public livestock listing does not provide specific withdrawal periods for Sulpha Bolus.  

Possible Adverse Effects

Sulfonamides are generally tolerated at appropriate doses, but possible adverse reactions may include:

• Reduced appetite
• Gastrointestinal upset
• Hypersensitivity reactions
• Crystalluria/urinary complications, particularly when hydration is inadequate
• Renal effects in susceptible or dehydrated animals
• Rare hematological abnormalities with prolonged treatment

Any significant or unexpected reaction should be evaluated by a veterinarian.

Storage

Store according to the instructions on the current manufacturer-approved label.

Keep in a cool, dry place, protected from direct sunlight, excessive heat and moisture.

Keep out of reach of children.

Important Warning

FOR ANIMAL TREATMENT ONLY. NOT FOR HUMAN USE.

Contains Sulphadimidine 5 g per bolus – a sulfonamide antibacterial medicine.

Use only under the prescription/direction of a Registered Veterinary Practitioner.

Responsible antimicrobial use is important. Use for appropriately diagnosed susceptible bacterial infections and observe the current manufacturer's milk and meat withdrawal instructions.

Rayavets Short Description

SULPHA Bolus by Zenex Animal Health India Pvt. Ltd. is a veterinary sulfonamide antibacterial medicine for cattle, buffaloes, sheep and goats, containing Sulphadimidine IP 5 g per bolus. It is used for susceptible bacterial infections, particularly calf scours, bacterial enteritis and acute bacterial infections. Historical manufacturer guidance recommends an initial oral dose of 1–2 boli per 50 kg body weight, followed by half the initial dose daily for 3–5 days. Treatment should be given under the direction of a Registered Veterinary Practitioner, with adequate drinking water available and applicable milk/meat withdrawal periods strictly observed. For animal treatment only.