Duraprogen® Injection 3 ML

Manufacturer/Marketer: Provimi Animal Nutrition India Pvt. Ltd. / Vetcare 
Product Type: Veterinary Injectable Reproductive Hormone
Therapeutic Class: Progestogen • Pregnancy-Support Hormone
Active Ingredient: Hydroxyprogesterone Caproate
Target Species: Primarily cattle and buffaloes, as directed by a veterinarian
Pack Size: 3 ml ampoule 

Composition – Each ml contains:
Hydroxyprogesterone Caproate I.P. — 250 mg (0.25 g)
Benzyl Alcohol I.P./B.P. — 0.02 ml (preservative)
Oily base — q.s. 

Therefore, a 3 ml ampoule contains 750 mg Hydroxyprogesterone Caproate.

Clinical Description:
Duraprogen is a long-acting depot progestogen injection containing Hydroxyprogesterone Caproate. It provides progesterone-like hormonal support to the reproductive tract and is intended for reproductive disorders in which progesterone therapy is indicated. Progesterone supports implantation and pregnancy and reduces uterine motility. 

Indications:
The 3 ml presentation is described by product information particularly for threatened abortion and uterine prolapse. Duraprogen product information also describes progesterone therapy for maintenance of pregnancy, early embryonic mortality associated with low progesterone levels and habitual abortion. 

Dosage & Administration:
For the 3 ml presentation, manufacturer catalogue information specifies:

Threatened abortion: 3 ml IM, with treatment repeated 2–3 times at weekly intervals when required.
Uterine prolapse: 3 ml IM, with a repeat dose on the 3rd day if necessary. 

Administration should be intramuscular (IM) and the exact treatment schedule should be determined by a veterinarian after reproductive examination.

Key Benefits:
Duraprogen provides prolonged progestogenic support and may help maintain pregnancy, support implantation and placental development, reduce excessive uterine activity and support pregnancy where inadequate progesterone is considered a contributing factor. 

Precautions:
For veterinary use only. This is a prescription hormonal medicine and should be administered only under the supervision of a Registered Veterinary Practitioner. The reproductive status and cause of abortion risk or prolapse should be properly evaluated before treatment. Do not use hormonal therapy as a substitute for appropriate treatment of infectious, nutritional, traumatic or other underlying reproductive disorders.

Possible Adverse Effects:
Hormonal preparations may cause local injection-site reactions or reproductive/endocrine effects in susceptible animals. Observe the animal following administration and seek veterinary advice if any significant or unexpected reaction develops.

Storage:
Store according to the conditions specified on the original manufacturer pack. Protect from excessive heat and direct light. Do not use if the solution is unclear or contains suspended matter, and do not use after the stated expiry date. 

Withdrawal Period:
One available Duraprogen product listing specifies milk: minimum 7 days and meat: minimum 28 days. Because withdrawal requirements can vary with the approved label and jurisdiction, Rayavets should verify these periods against the current Indian manufacturer pack/package insert before publishing them as definitive. 

Important Warning:
For veterinary use only. Prescription veterinary hormone. Threatened abortion can have infectious, metabolic, nutritional or reproductive causes; therefore, Duraprogen should be used only after veterinary assessment.

Rayavets Short Description:
Duraprogen Injection 3 ML by Provimi/Vetcare is a long-acting reproductive hormone containing Hydroxyprogesterone Caproate 250 mg/ml (750 mg/3 ml). It provides progestogenic support and is indicated particularly for threatened abortion and uterine prolapse, along with other progesterone-responsive reproductive conditions. The 3 ml presentation is administered intramuscularly under veterinary supervision, with repeat treatment depending on the clinical condition.