DUROMECT® Injection 50 ML

Manufacturer/Marketer: Zenex Animal Health India Pvt. Ltd.
Product Type: Veterinary Injectable Broad-Spectrum Antiparasitic
Therapeutic Category: Endectocide / Anthelmintic / Ectoparasiticide / Macrocyclic Lactone
Target Species: Cattle, Sheep, Goats & Swine
Presentation: 50 mL vial; also available as 10 mL vial
Route: Intramuscular (IM) / Subcutaneous (SC), depending on species
Prescription Status: Veterinary medicine – use under veterinary supervision

Zenex currently lists DUROMECT as an anti-parasitic injection and confirms 10 mL and 50 mL presentations. 

Composition

Each 1 mL contains:

• Doramectin – 10 mg
• Benzyl Alcohol IP – 20 mg as preservative
• Oily base q.s. 

This corresponds to a 1% w/v Doramectin injectable formulation.

Doramectin belongs to the macrocyclic lactone/avermectin class of antiparasitic medicines and provides activity against a broad range of susceptible internal and external parasites.

Clinical Description

DUROMECT Injection is a long-acting, broad-spectrum injectable antiparasitic preparation containing Doramectin 10 mg/mL.

Doramectin acts against susceptible nematodes and arthropod parasites, making the product useful for simultaneous control of important internal and external parasitic infestations in livestock. Historical product literature describes activity against gastrointestinal roundworms, lungworms, sucking lice, mange mites, screwworms and single-host ticks. Scribd

Doramectin acts primarily on parasite glutamate-gated chloride channels, resulting in paralysis and death of susceptible parasites.

Indications / Recommended Uses

DUROMECT is used for treatment and control of susceptible parasites including:

• Gastrointestinal roundworms
• Lungworms
• Parafilaria
• Eyeworms
• Screwworms
• Sucking lice
• Mange mites
• Single-host ticks
• Internal and external parasitic infestations in livestock
• In swine, control of susceptible roundworms, lungworms, lice and sarcoptic mange mites 

The exact parasite spectrum can vary by host species, so treatment should follow veterinary diagnosis and the approved product label.

Dosage & Administration

Cattle:
200 mcg Doramectin/kg body weight, equivalent to 1 mL per 50 kg body weight, administered IM or SC.

Sheep & Goats:
200 mcg/kg body weight, equivalent to 1 mL per 50 kg body weight, administered IM or SC.

Swine:
300 mcg/kg body weight, equivalent to approximately 1 mL per 33 kg body weight, administered IM. 

Use sterile injection equipment and appropriate aseptic technique.

Dosage and treatment schedule should ultimately be as directed by the Registered Veterinary Practitioner.

Key Benefits

DUROMECT provides:

• Broad-spectrum antiparasitic activity
• Control of both internal and external parasites
• Activity against important gastrointestinal roundworms
• Control of lungworms
• Activity against lice and mange mites
• Control of susceptible ticks
• Long-acting activity of Doramectin
• Convenient low-volume injectable administration
• Useful antiparasitic coverage for livestock herd-health programs. 

Contraindications & Precautions

Do not use in animals with known hypersensitivity to Doramectin or other components of the formulation.

Accurately determine the animal's body weight to avoid under- or overdosing.

Use the correct administration route for the target species.

Repeated and indiscriminate use of the same class of anthelmintic may contribute to parasite resistance. Parasite-control programs should therefore be developed with veterinary guidance.

Do not administer intravenously.

Use in young, debilitated, pregnant or breeding animals according to the current product label and veterinary advice.

Withdrawal Period

An older product reference for DUROMECT reports:

Milk: 7 days
Meat: 28 days 

However, because withdrawal requirements can change by species, jurisdiction and current approved label, Rayavets should use the withdrawal period printed on the current Zenex pack/insert as the controlling instruction for food-producing animals.

Possible Adverse Effects

Doramectin is generally well tolerated when used at the recommended dose.

Possible reactions may include:

• Temporary pain or swelling at the injection site
• Local tissue reaction
• Rare hypersensitivity reactions
• Neurological signs in cases of substantial overdose or unusual susceptibility

Any significant or unexpected reaction should be evaluated by a veterinarian.

Storage

Store below 30°C, in a dry place and protected from direct sunlight. 

Keep the vial properly closed and protected from contamination.

Keep out of reach of children.

Important Warning

FOR ANIMAL TREATMENT ONLY. NOT FOR HUMAN USE.

Contains Doramectin 10 mg/mL.

Use according to the recommended species-specific dose and route and under the guidance of a Registered Veterinary Practitioner.

For food-producing animals, strictly observe the applicable milk and meat withdrawal periods stated on the current manufacturer-approved label.

Rayavets Short Description

DUROMECT Injection 50 ML by Zenex Animal Health India Pvt. Ltd. is a long-acting, broad-spectrum veterinary endectocide containing Doramectin 10 mg/mL. It is used for treatment and control of susceptible gastrointestinal roundworms, lungworms, lice, mange mites, screwworms, ticks and other internal and external parasites in livestock. The usual dose is 200 mcg/kg (1 mL/50 kg body weight) in cattle, sheep and goats by IM/SC injection, while swine receive 300 mcg/kg (approximately 1 mL/33 kg) by IM injection. Use under the direction of a Registered Veterinary Practitioner and observe the current manufacturer's withdrawal instructions. For animal treatment only.